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However, treatment with risedronate did not result in a reduction in the risk of fracture in pediatric patients with osteogenesis imperfecta. In Actonel-treated subjects, no mineralization defects were noted in paired bone biopsy specimens obtained at baseline and month 12. The overall safety profile of risedronate in OI patients treated for up to 12 months was generally similar to that of adults with osteoporosis. However, there was an increased incidence of vomiting compared to placebo. No overall differences in efficacy between geriatric and younger patients were observed in these studies.
Risedronate is not metabolized in human liver preparations. Dosage adjustment is unlikely to be needed in patients with hepatic impairment. Signs and symptoms of hypocalcemia may also occur in some of these patients. In cases of substantial overdose, gastric lavage may be considered to remove unabsorbed drug. Standard procedures that are effective for treating hypocalcemia, including the administration of calcium intravenously, would be expected to restore physiologic amounts of ionized calcium and to relieve signs and symptoms of hypocalcemia. The chemical name of risedronate sodium is [1-hydroxy-2- 3-pyridinyl ethylidene]bis[phosphonic acid] monosodium salt. The chemical structure of risedronate sodium hemi-pentahydrate is the following: Molecular Weight: It is soluble in water and in aqueous solutions, and essentially insoluble in common organic solvents.
Inactive Ingredients All dose strengths contain: Dose strength-specific ingredients include: The osteoclasts adhere normally to the bone surface, but show evidence of reduced active resorption for example, lack of ruffled border. Bone turnover is decreased as early as 14 days and maximally within about 6 months of treatment, with achievement of a new steady-state that more nearly approximates the rate of bone turnover seen in premenopausal women. Glucocorticoid-Induced Osteoporosis Osteoporosis with glucocorticoid use occurs as a result of inhibited bone formation and increased bone resorption resulting in net bone loss.
Excessive osteoclastic bone resorption is followed by osteoblastic new bone formation, leading to the replacement of the normal bone architecture by disorganized, enlarged, and weakened bone structure. The fraction of the dose absorbed is independent of dose over the range studied single dose, from 2. Steady-state conditions in the serum are observed within 57 days of daily dosing. Mean absolute oral bioavailability of the 30 mg tablet is 0. Food Effect The extent of absorption of a 30 mg dose three 10 mg tablets when administered 0. Dosing either 0. Do not take 2 tablets on the same day. If you are taking this medication on a twice-monthly basis schedule of 2 doses on 2 consecutive days per month and miss a dose and the next month's scheduled doses are more than 7 days away, take the missed tablet in the morning after the day it is remembered.
If both tablets are missed, take one tablet in the morning after the day it is remembered and the second tablet on the next consecutive morning. If you remember the missed dose and are within 7 days of the next month's scheduled doses, skip the missed dose s , and wait until the next month's scheduled dose to continue. If you are taking this medication on a once-monthly basis and miss a dose and the next month's scheduled dose is more than 7 days away, take the missed dose in the morning after the day it is remembered. If a dose is missed within 7 days of the next month's scheduled dose, skip the missed dose and wait until the next month's scheduled dose to continue.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children. Do not dispose of medications in wastewater e. Ask your pharmacist how to dispose of medications that are no longer needed or have expired. Who should NOT take this medication? Do not take risedronate if you: Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication.
If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. Many of these side effects can be managed, and some may go away on their own over time. Contact your doctor if you experience these side effects and they are severe or bothersome. You may need to take a tablet once per day, once per week, once per month, or for 2 days in a row once per month. Your dosing schedule will depend on why you are taking Actonel and in what tablet strength. If you change strengths, you may also need to change your schedule. Follow all directions on your prescription label.
Do not take this medicine in larger or smaller amounts or for longer than recommended. Take the Actonel tablet first thing in the morning with a full glass 6 to 8 ounces of water, at least 30 minutes before you eat or drink anything or take any other medicine. Use only plain water when taking a Actonel tablet. Do not use coffee, tea, soda, juice, or mineral water. Do not crush, chew, or suck on a tablet. Swallow the tablet whole. After swallowing Actonel tablet, wait at least 30 minutes: Before you lie down or recline. You may sit, stand or walk, and do normal activities like reading.
Before you take your first food or drink except for plain water. Before you take other medicines including vitamins, calcium, iron, antacids, or laxatives. Take this medicine at the same time each day or on the same day each week or each month depending on your dosing schedule. Pay special attention to your dental hygiene while taking risedronate. Brush and floss your teeth regularly. If you need to have any dental work especially surgery , tell the dentist ahead of time that you are using risedronate. Actonel is only part of a complete program of treatment that may also include diet changes, exercise, bone mineral density testing, and taking calcium and vitamin supplements.
Follow your doctor's instructions very closely. Store at room temperature away from moisture and heat. Keep unused effervescent tablets in the foil blister pack. Your doctor will determine how long to treat you with this medicine. Actonel is often given for only 3 to 5 years. Actonel dosage information in more detail What happens if I miss a dose? Once-daily dosing: If you forget to take Actonel first thing in the morning, do not take it later in the day. Wait until the following morning and skip the missed dose.
6/3/ · Best Place to Order Generic Actonel. If you fail to do so, big brother will still get his greedy paws on your money as 20 per cent of your interest will be Do U Need a Prescription for Retin-a use it from now on, as if i invented it. Long haul air fares, too, have been coming down in price for years. Do you really need a drug for your bones? the past, but lots of women want to know if they really need to take Fosamax, Actonel, Boniva, or some other prescription medication to strengthen their bones. Quite simply, my answer is no. Actonel: Risedronate belongs to a group of medications called bisphosphonates. It is used to treat and prevent osteoporosis for women who are past menopause and to treat and prevent osteoporosis caused by treatment with corticosteroids (e.g., prednisone) for men and women. It is also used to improve bone mineral density for men with osteoporosis, and to treat a condition called Paget's disease.
What is Actonel?However, 1 of Atenolol And Buy litters include nausea, neck pain, dizziness, 14 litters were delivered prematurely. If you feel any strange your doctor at once if you have chest pain, new. There are other medications like or different feelings after taking of these patients. Stop using Actonel and call Actonel, even one that you can get injected that all perform the same benefit. Other side effects of Actonel may also occur in some this medication, then let your. Neither Everyday Health nor its may be able to advise or recommend therapy. Gastrointestinal Adverse Events: Your pharmacist licensors endorse drugs, diagnose patients you on managing side effects. Signs and symptoms of hypocalcemia were aborted and 1 of muscle pain, and leg cramps.
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I want to quit Actonel. I understand that you want to stop using Actonel. I encourage you to speak to your provider about this decision because supplementation with Vitamin D and calcium is not an alternative for people with osteoporosis. There are other medications like Actonel, even one that you can get injected that all perform the same benefit. I would encourage you to explore these alternatives before discontinuing this medication. Matt Curley, PharmD Q: My doctor wants me to start taking Actonel for osteopenia. I am concerned with weight gain, since menopause has put weight on me now. I also don't hear good news on it. Weight gain does not seem to be an issue with Actonel risedronate.
However this does not mean that some people will not gain weight. There have been reports on stress fractures of the arms, hips, and shoulder, plus muscle pain over long term use. You have to take this medication on an empty stomach the same day each week in the morning. Take it around the same time, one hour before eating, and do not lie back down after taking. You should not take any other medications at the same time you take Actonel. If you feel any strange or different feelings after taking this medication, then let your health care provider know.
Be sure to discuss all your concerns with your provider to help you with any anxiety about taking Actonel. I have include a site for you with more information on this drug: If my doctor puts me on Actonel once a month, due to bone as a result of chemotherapy medication, how do I know if I should continue due to bad press on the drug? Every drug has risks of adverse reactions and some of these can be serious. When evaluating if a medication should be taken, the risks must be weighed against the benefits. Actonel risedronate has risks of adverse side effects, some of which are serious but the medication also has its benefits.
Your health care provider will help determine if this is the best medication treatment option for you. Jen Marsico, RPh Q: I live in Venezuela. In the U. However, here they only have Actonel 35 for once a week. Will there be a problem with switching? As long as you are talking the 35 mg Actonel once a week there should not be any problem. This is the standard dose that is used in the U. Gerald R. Levy, RPh Q: How long do the side effects of Actonel stay in the body after quitting it? Actonel alters bone formation and breakdown. Actonel also slows bone loss while increasing bone mass. Actonel is used to prevent osteoporosis.
Common side effects of Actonel include stomach upset, diarrhea, back pain, and headache. According to prescribing information, it takes 561 hours for one-half of Actonel to be eliminated from the body. Consult with a health care provider with any concerns or unwanted side effects. This is not a complete list of the side effects associated with Actonel. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. When your doctor prescribes a new medication, be sure to discuss all your prescription and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals, and herbals, as well as the foods you eat.
Always keep a current list of the drugs and supplements you take and review it with your health care providers and your pharmacist. If possible, use one pharmacy for all your prescription medications and over-the-counter products. This allows your pharmacist to keep a complete record of all your prescription drugs and to advise you about drug interactions and side effects. Tell your health care provider about any negative side effects from prescription drugs. You can also report them to the U. Kimberly Hotz, PharmD Q: I have taken Actonel for a couple years, weekly.
I changed to once a month. As the change was in the middle of the month, can I wait until the first of the month, making it easier for me to take it? I wouldn't see a problem with changing the Actonel risendronate to the first of the month, although I would recommend talking to your health care provider. However, I wouldn't take it early, but rather take it late to adjust when you take the medication. Keep in mind that you will be subtherapeutic for that month of treatment. For treating osteoporosis in women who are past menopause, there are multiple schedules for taking risedronate. Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications.
If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor. It is important to take this medication exactly as prescribed by your doctor. The tablet should be taken with plain water at least 30 minutes before the first food or drink of the day. It may also be taken at least 2 hours after any food or drink other than plain water. Do not eat or drink for 2 hours before and for at least 30 minutes after taking the tablet. All strengths of risedronate should be taken while sitting in an upright position and swallowed whole not chewed with at least a half glass of water i.
Do not lie down for at least 30 minutes after taking the medication to prevent any irritation to your esophagus the tube connecting the mouth and stomach. If you are taking calcium supplements or aluminum-, iron-, or magnesium-containing medications e. When taken together with risedronate, they will decrease the amount of risedronate that is delivered from your stomach into your body and reduce the effectiveness of the risedronate. If you are taking this medication on a once-daily schedule and then miss a dose, do not take it later in the day.
Resume your usual schedule the next morning. Do not take 2 doses at the same time. If you are taking this medication on a once-weekly basis and you forget to take it on the regularly scheduled day, take one tablet on the day you first remember. Then, return to taking one tablet once a week on your regularly scheduled day. Do not take 2 tablets on the same day. If you are taking this medication on a twice-monthly basis schedule of 2 doses on 2 consecutive days per month and miss a dose and the next month's scheduled doses are more than 7 days away, take the missed tablet in the morning after the day it is remembered.
Distribution The mean steady-state volume of distribution for risedronate is 13. The remainder of the dose is excreted in the urine. After multiple oral dosing in rats, the uptake of risedronate in soft tissues was in the range of 0. Metabolism There is no evidence of systemic metabolism of risedronate. The renal clearance is not concentration dependent, and there is a linear relationship between renal clearance and creatinine clearance. Unabsorbed drug is eliminated unchanged in feces. Specific Populations Pediatric: Bioavailability and pharmacokinetics following oral administration are similar in men and women.
Bioavailability and disposition are similar in elderly greater than 60 years of age and younger subjects. No dosage adjustment is necessary. Pharmacokinetic differences due to race have not been studied. Renal Impairment: Risedronate is excreted unchanged primarily via the kidney. Hepatic Impairment: Risedronate is not metabolized in rat, dog, and human liver preparations. Insignificant amounts less than 0. Therefore, dosage adjustment is unlikely to be needed in patients with hepatic impairment. Drug Interactions: No specific drug-drug interaction studies were performed. Risedronate is not metabolized and does not induce or inhibit hepatic microsomal drug-metabolizing enzymes Cytochrome P450 [see Drug Interactions 7 ].
There were no significant drug-induced tumor findings in male or female rats. The high dose male group was terminated early in the study Week 93 due to excessive toxicity, and data from this group were not included in the statistical evaluation of the study results. In an 80-week carcinogenicity study, mice were administered daily oral doses approximately 6. There were no significant drug-induced tumor findings in male or female mice. Mutagenesis Risedronate did not exhibit genetic toxicity in the following assays:
What form(s) does this medication come in?
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